Cardiometabolic risk and structural brain development in a large community-based U.S. cohort.

ABSTRACT:

Objective

Cardiometabolic risk factors are already detectable in childhood and adolescence, but their relations to the developing brain remains unclear. The current study tested whether poorer cardiometabolic health is associated with brain structure and microstructure development in 10-17-year-old youth.

Methods

Using the Adolescent Brain Cognitive Development Study, we analysed data from 3,527 participants with 4,433 observations across three waves. We related anthropometric (body-mass index, waist circumference), cardiovascular (systolic and diastolic blood pressure, resting heart rate), and metabolic (haemoglobin A1c, high-density lipoprotein cholesterol) indices to global cortical thickness and surface area, and to white matter fractional anisotropy and mean diffusivity

SUBMITTER: Beck D 

PROVIDER: S-EPMC12633619 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature