Methotrexate alleviates chronic inflammation in a Drosophila model.

ABSTRACT: Growth signals and immune responses in cancer typically originate in the same compartments. In early stages of tumor development, inflammatory cells trigger responses against growing cancers. At a molecular level, it is unclear how the innate immune system recognizes tumorigenesis. At later stages, cancer cells resist cell death and evade immune detection, thereby suppressing anti-tumor responses and promoting cancer hallmarks. Often, chronic inflammatory responses become tumor friendly and incline towards tumorigenesis disturbing metabolic signaling, thereby rewiring nutritional supply for cancer growth. The precise connecting link between cancer, nutrition and metabolism remains unclear. Drosophila provides an ideal platform to explore the links between hyperactive immune signaling, defe

SUBMITTER: Gautam DK 

PROVIDER: S-EPMC12633795 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature