Voluntary Exercise Attenuates Tumor Growth in a Preclinical Model of Castration-Resistant Prostate Cancer.

ABSTRACT:

Purpose

To examine the effects of voluntary wheel running on tumor growth and explore potential intratumoral molecular pathways responsible for the beneficial effects of voluntary wheel running on tumor formation and progression in a mouse model of castration-resistant prostate cancer (CRPC).

Methods

Male immunodeficient mice (SCID) were castrated and subcutaneously inoculated with human CWR-22RV1 cancer cells to construct CRPC xenograft model before assigned to either voluntary wheel running (VWR) or sedentary (SED) group ( n = 6/group). Tumor size was measured and calculated throughout the study. After 3 wk, tumor tissues were collected. mRNA expression of markers of DNA replication, androgen receptor (AR) signaling, and mitochondrial dynamics was determined by quantitativ

SUBMITTER: Berger N 

PROVIDER: S-EPMC12633799 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature