Omicron surge impact on acute kidney injury in ICU patients: A study using the ISARIC COVID-19 database.

ABSTRACT:

Background

Acute Kidney Injury (AKI) is common among COVID-19 patients and is associated with a higher risk of death. Compared to earlier COVID-19 variants, Omicron has reduced mortality. To study the relationship between Omicron and AKI, we conducted the first international study using the global International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 global dataset.

Methods

This prospective observational study aims to characterise AKI in a cohort of 3,908 COVID-19 patients admitted to the intensive care unit (ICU) across six countries. Clinical characteristics were compared between Omicron and pre-Omicron patients. Multivariable logistic regression was used to analyse the relationship between the Omicron variant and AKI. AKI was defined b

SUBMITTER: Dai D 

PROVIDER: S-EPMC12633887 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature