Serology change-based clinical interpretation of indeterminate serostatus post-hepatitis B virus infection in people living with HIV.

ABSTRACT: After hepatitis B virus (HBV) infection in people living with HIV (PLWH), various forms of indeterminate serostatuses, including "isolated anti-HBc (IAHBc)", are observed, but the current interpretation for their HBV immunity seems to be optimistic. This single-center, retrospective cohort study of 1,461 PLWH included individuals with past natural HBV infection and negative history of HBV vaccination. Further, based on their most recent serology status, the selected individuals were classified into either 1) seroconversion, 2) chronic infection, or 3) indeterminate groups. PLWH of the latter group (with indeterminate serostatus) were defined as neither seroconversion [HBsAg(-)/anti-HBs(+)/anti-HBc(+)] nor chronic infection [HBsAg(+)/anti-HBs(-)/anti-HBc(+)]; chronological sub-serostatus of

SUBMITTER: Kinai E 

PROVIDER: S-EPMC12633944 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature