Long-term outcomes of benznidazole treatment in chronic Chagas disease: A 27-year cohort study of parasitological cure and death in the Jequitinhonha Valley, Brazil.

ABSTRACT:

Background

Chagas disease (CD) is a neglected tropical infection prevalent in rural areas of Latin America. The etiological treatment is indicated for patients with both acute and chronic phases of CD, except in the most advanced clinical stage of the disease. However, there are still several divergences regarding the benefits of etiological treatment in chronic CD as far as the parasitological cure and survival/mortality outcomes. The present study aimed at verifying the impact of benznidazole (BZ) treatment on parasitological cure and death of patients with chronic CD at 9, 13, and 27 years post-treatment.

Objective

This study aimed to verify the impact of BZ-treatment on parasitological cure and death of patients with chronic CD at 9, 13, and 27-year follow-up.

Methods

SUBMITTER: Assis JCSO 

PROVIDER: S-EPMC12633969 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature