In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.

ABSTRACT: Burst firing is an important property of neuronal activity, thought to enhance sensory encoding. While previous studies show significant differences in burst firing between in vivo and in vitro conditions, how burst firing contributes to neural coding in vivo and how it is modulated by underlying biophysical mechanisms when neurons are under active synaptic bombardments remains poorly understood. Here, we combined intracellular recordings and computational modeling to investigate how cellular and synaptic mechanisms can explain the in vivo firing activity of electrosensory lateral line lobe (ELL) pyramidal cells in Apteronotus leptorhynchus. We developed a biophysically detailed compartmental model incorporating voltage-gated currents, NMDA receptor-mediated calcium (Ca2 + ) influx, Ca2 + 

SUBMITTER: Akhshi A 

PROVIDER: S-EPMC12633970 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature