Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.

ABSTRACT: Adolescent neurodevelopment of affective and cognitive control, crucial for healthy functioning and impaired transdiagnostically, is supported by refinements between the amygdala and prefrontal cortex (PFC). Due to technical limitations, fronto-amygdala connectivity remains poorly characterized. Here, we leverage multimodal longitudinal 7 T neuroimaging data in 143 healthy participants aged 10-32 to examine developmental trajectories between subject-specific amygdala nuclei and PFC subregions. We find age-related functional connectivity changes between the lateral PFC and basolateral amygdala, ventral portions of the PFC and central amygdala, and the anterior cingulate cortex and corticoamygdaloid transition area. Variability in connectivity strength relates to individual differences in af

SUBMITTER: Ojha A 

PROVIDER: S-EPMC12634048 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature