Targeting p38 MAPK signaling pathway:  Quercetin as a novel therapy for TMJ synovitis.

ABSTRACT: Temporomandibular joint (TMJ) synovitis is a chronic inflammatory condition prevalent in temporoman-dibular disorders, characterized by synovial inflammation and bone degradation. Quercetin, a natural flavonoid with diverse bioactive properties, is investigated for its potential in ameliorating TMJ synovitis by targeting the p38 MAPK pathway. Using network pharmacology and in vitro and in vivo models, the effects of quercetin on synoviocytes and inflammatory responses were evaluated. Results showed quercetin's significant inhibition of synoviocyte proliferation, promotion of apoptosis and reduction of inflammatory cytokines. Moreover, quercetin demonstrated stability in binding to critical targets like MAPK14 and led to downregulation of phosphorylated p38 MAPK and JNK. In

SUBMITTER: Cheng M 

PROVIDER: S-EPMC12634065 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature