Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database.

ABSTRACT:

Background and aims

Higher levels of lipoprotein(a) drive increasing risk of atherosclerotic cardiovascular disease (ASCVD) in otherwise healthy individuals regardless of sex and race/ethnicity. This study aimed to evaluate whether this is also true for recurrent ASCVD, and whether LDL cholesterol-lowering therapy possibly mitigates such a relationship.

Methods

In US medical claims between 2012 and 2022 for 340 million individuals, 273 770 had diagnosed ASCVD and lipoprotein(a) measured in nmol/L. These women (n = 117 269; 43%) and men (n = 156 501; 57%) included Black (n = 22 451; 8%), Hispanic (n = 24 606; 9%), and White (n = 161 165; 59%) individuals.

Results

Lipoprotein(a) levels were higher in women vs men and in Black vs Hispanic and White individuals. During a

SUBMITTER: MacDougall DE 

PROVIDER: S-EPMC12634116 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature