Assessing the 10/66 dementia classification algorithm for international comparative analyses with the United States.

ABSTRACT: Cross-national comparisons of dementia prevalence are essential for identifying unique determinants and cultural-specific risk factors, but methodological differences in dementia classification across countries hinder global comparisons. This study maps the 10/66 algorithm for dementia classification, widely used and validated in low- and middle-income countries (LMICs), to the US Aging, Demographics, and Memory Study (ADAMS), the dementia sub-study of the Health and Retirement Study, and assesses its performance in ADAMS. We identified the subset of 10/66 algorithm items comparably measured in ADAMS, then used these items to retrain the 10/66 algorithm against the ADAMS clinical dementia diagnosis, using k-fold cross-validation to assess performance. We compared the modified 10/66 algorit

SUBMITTER: Llibre Guerra JJ 

PROVIDER: S-EPMC12634119 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature