Adjusting for selection bias due to missing eligibility criteria in emulated target trials.

ABSTRACT: Target trial emulation (TTE) is a popular framework for observational studies based on electronic health records (EHRs). A key component of this framework is determining the patient population eligible for inclusion in both a target trial of interest and its observational emulation. Missingness in variables that define eligibility criteria, however, presents a major challenge in determining the eligible population when emulating a target trial with an observational study. In practice, patients with incomplete data are almost always excluded from analysis despite the possibility of selection bias, which can arise when participants with observed eligibility data are fundamentally different than excluded individuals. Despite this, to our knowledge, very little work has been done to mitigate t

SUBMITTER: Benz L 

PROVIDER: S-EPMC12634130 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature