Revisiting Glomerulopathy in Clusterin Knockout Mice: A Mouse Model of Human Immunotactoid Glomerulopathy.

ABSTRACT:

Aim

Clusterin (CLU) is a chaperone-like glycoprotein, and CLU knockout (KO) mice spontaneously develop age-dependent glomerulopathy with microtubule formation. However, its clinical relevance has not been confirmed yet. Immunotactoid glomerulopathy (ITG) is a clinicopathologic entity of glomerulonephritis characterised by glomerular deposits of electron dense microtubules. This study was to re-examine the glomerulopathy in CLU KO mice as compared with the pathological features of human ITG.

Methods

Kidney specimens from both wild type C57BL/6 (B6) and CLU-KO B6 mice were analyzed with haematoxylin and eosin, Masson-Trichrome, and Congo-red staining. IgG and DNAJB9 were detected by immunohistochemical staining, and the electron-dense mesangial deposits by transmission electro

SUBMITTER: Li X 

PROVIDER: S-EPMC12634156 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature