BST2 Drives Epithelial Ovarian Cancer Progression via Macrophage M2 Polarization, Neural Remodeling, and Immunosuppressive Microenvironment Formation.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) ranks as the most lethal of gynecological cancers. Despite advances in therapeutic interventions that have marginally extended survival rates, the early detection and management of EOC pose significant hurdles. Consequently, identifying novel therapeutic targets is imperative for enhancing the survival outcomes of patients afflicted with this malignancy.

Purpose

This research is aimed at exploring the functions of Bone Marrow Stromal Antigen 2 (BST2) in the pathogenesis of EOC and their influence on macrophage polarization, evaluating their viability as targets for immunotherapy.

Methods

Gene expression profiles and clinical data of EOC patients were retrieved from the TCGA repository to develop prognostic models centered on

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12634163 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature