Association of Intraindividual Difference in Cystatin C and Creatinine Estimated Glomerular Filtration Rate With Diabetes.

ABSTRACT:

Introduction

Declined renal function is closely linked to diabetes. However, it remains unclear whether the intraindividual difference between cystatin C- and creatinine-based estimated glomerular filtration rates (eGFRdiff) is associated with diabetes. This study was aimed at examining the association between eGFRdiff and prevalent diabetes in a nationally representative cohort of Chinese adults.

Methods

We analyzed data from 11,869 adults aged ≥ 45 years participating in the China Health and Retirement Longitudinal Study (CHARLS), including 2279 individuals with diabetes. We calculated eGFRdiff as the absolute difference between cystatin C- and creatinine-based eGFR levels. Multivariable logistic regression and restricted cubic spline models were used to assess the associa

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12634172 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature