Lipidome's Role in Diabetic Retinopathy Subtypes via Inflammation: Mendelian Randomization and Mediation Analysis.

ABSTRACT:

Purpose

This study aims to explore the causal relationships between plasma lipidome, inflammatory cytokines, and diabetic retinopathy (DR) subtypes using a two-sample Mendelian randomization (MR) approach and mediation analysis.

Design

Mendelian randomization study and mediation analysis.

Subjects

Genome-wide association study (GWAS) data of 179 plasma lipid species and 91 inflammatory cytokines from the public GWAS database. Genome-wide association study data of DR and its subtypes from the FinnGen consortium.

Methods

Primary causal estimates were derived via inverse-variance weighted method, complemented by 4 sensitivity methods (weighted median, MR-Egger, simple mode, weighted mode). Mediation analysis was performed to determine the extent to which inflammat

SUBMITTER: Xu X 

PROVIDER: S-EPMC12634289 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature