In Silico Comparison of Photon Versus Proton Based Stereotactic Body Radiotherapy With Increasing Maximum Peak Dose for Treatment of Primary Renal Cell Carcinoma.

ABSTRACT:

Purpose

Photon based Stereotactic Body Radiotherapy (PH-SBRT) has emerged as a promising option for treatment of primary renal cell carcinoma (RCC), however is associated with decrements in long-term kidney function and toxicity to adjacent organs at risk (OARs).

Materials and methods

We compared proton (PT) based SBRT versus PH-SBRT regarding target coverage, OARs, and maximum peak doses of 125% and 142%. All variables were compared using student t-tests.

Results

Target coverage was comparable between plans for gross tumor volume (GTV) and clinical target volume (CTV). OARs were greatly spared by PT-SBRT including small bowel; V5 Gy to V25 Gy and maximum dose (10.47, 20.22, P = .02), large bowel; V5 Gy to V25 Gy and maximum dose (16.16, 23.90, P

SUBMITTER: Shaaban SG 

PROVIDER: S-EPMC12634305 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature