Establishment and validation of a prognostic risk model based on ADME-related genes in breast cancer.

ABSTRACT:

Background

The processes of absorption, distribution, metabolic action, and elimination (ADME) affect the advancement of cancer and the development of resistance to therapies. This study examined ADME-related genes in breast cancer (BRCA) mechanisms and their associations with BRCA.

Methods

BRCA datasets were analyzed to identify genes with differential expression in BRCA compared to normal tissues, focusing on ADME-related genes (ADME-RGs). Stepwise regression analyses identified prognostic genes, which were used to develop a risk assessment model. BRCA patients were scored and classified into risk categories, with survival outcomes compared across groups. A predictive model incorporating key prognostic indicators estimated patient survival rates. Mechanisms were explored t

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12634386 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature