The endogenous T cell landscape is reshaped by CAR-T cell therapy and predicts treatment response in multiple myeloma.

ABSTRACT: While most patients initially respond to CAR-T cell treatment, responses often are not durable and subsequent lines of immunotherapy show diminishing success. In this study, we investigated the co-evolutionary dynamics between CAR-T cells and the immune microenvironment in myeloma patients undergoing anti-BCMA CAR-T cell therapy at single-cell resolution. Our findings highlight the transformative impact of CAR-T cell treatment on the endogenous T cell landscape. We identify a novel transitional CD8 + T cell population that is predictive of poor treatment outcomes. The emergence of this population coincides with the depletion of the endogenous T cell repertoire and compositional evolution of functional T cell subsets. These changes in the endogenous T cell compartment induced by CAR-T cell

SUBMITTER: Frede J 

PROVIDER: S-EPMC12634420 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature