Acute myeloid leukaemia cells express high levels of androgen receptor but do not depend on androgen signaling for survival.

ABSTRACT: Male sex is associated with worse outcome in acute myeloid leukemia (AML) in many studies. We analyzed the survival of 4281 patients treated with intensive chemotherapy in the AML17 and AML19 trials based on sex. Men had a significantly lower remission rate than women. Men had a higher incidence of adverse cytogenetic features and a lower incidence of the relatively favorable NPM1 mutation. However, male sex was an independent risk factor for survival in multi-variate analysis. We hypothesized that androgen signaling in men could worsen outcomes by protecting AML cells from chemotherapy. We demonstrated high levels of androgen receptor (AR) expression in AML across cytogenetic risk groups. We showed the AR expression was induced by IL-6 signaling in vitro and correlates with poor overall s

SUBMITTER: Miraki-Moud F 

PROVIDER: S-EPMC12634449 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature