Associations of ambient temperature and heat waves with risks of hepatitis E in Jiangsu, China (2010-2023): A time-stratified case-crossover study.

ABSTRACT:

Background

Hepatitis E virus (HEV) causes substantial morbidity globally, with frequent outbreaks in low-resource settings due to fecal-oral transmission. Temperature and extreme heat may influence waterborne pathogens, but their impact on HEV risk is unclear.

Methods

We performed a time-stratified case-crossover study using 42,481 laboratory-confirmed hepatitis E cases reported in Jiangsu Province (2010-2023). Daily mean, maximum, and minimum temperatures were obtained from fixed-site monitoring data. We examined associations of short-term temperature (single-day and cumulative lags up to 21 days) and heat wave episodes with hepatitis E risk using conditional logistic regression. Heat waves were defined using percentile-based thresholds for consecutive days. Analyses were a

SUBMITTER: Yang L 

PROVIDER: S-EPMC12634450 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature