Reproducibility of Metabolic Mapping Using 2D Multi-Slice Short-TE and GABA-Edited Spin-Echo MRSI at 3T in a Single Protocol.

ABSTRACT: MRSI is a non-invasive tool for mapping metabolic distributions in multi-focal or other diseases where the location of abnormalities may be uncertain. High-concentration metabolites can be investigated at 3T using non-edited MRSI, whereas lower-concentration metabolites, such as GABA, typically require specialized editing techniques because of spectral overlap. This study reports on the reproducibility of a protocol containing both co-localized short-TE and GABA-edited multi-slice spin-echo 2D MRSI. Multi-slice, short-TE (TE 20 ms) and GABA-edited (TE 68 ms) MRSI at a nominal spatial resolution of 2.2 cm³ was performed twice (7 to 14 days apart) at 3T on 11 healthy volunteers (age range 7 to 43 years). Data analysis was performed in the "Osprey" software package, including retro

SUBMITTER: Zollner HJ 

PROVIDER: S-EPMC12634484 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature