The diagnostic value of global longitudinal strain on doxorubicin-induced cardiotoxicity in pediatric cancer patients: a cross-sectional study.

ABSTRACT:

Background

Chemotherapy is a critical modality in the treatment of pediatric cancer. However, the risk of adverse effects remains a significant challenge despite the considerable advancements in chemotherapy efficacy. Anthracyclines are a cornerstone in the treatment of various childhood cancers but are associated with a notable risk of cardiotoxicity. Early detection of cardiac dysfunction in pediatric cancer patients is vital to prevent progression to heart failure, with echocardiography being one of the primary modalities for such assessments. Speckle Tracking Echocardiography (STE) is a recommended method for the early detection of cardiotoxicity in adult cancer patients, although its application in the pediatric population remains limited. This study aims to assess the diagnos

SUBMITTER: Lesmanawati DAS 

PROVIDER: S-EPMC12634503 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature