A contemporary strain of RSV activates primary human monocytes after abortive infection.

ABSTRACT: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections worldwide, particularly affecting infants, older adults, and immunocompromised individuals. Understanding the cellular immune response to RSV infection is essential for developing effective treatments for infection and its complications. In this study, we investigated the susceptibility of blood-derived primary monocytes and monocytic THP-1 cells to infection with a contemporary RSV A-ON1 strain and characterized the subsequent cytokine and chemokine secretion, as well as the expression of surface markers involved in antigen presentation. Our findings demonstrate that primary monocytes and related THP-1 cells are permissive to abortive infection by RSV, leading to increased expression of proinflammat

SUBMITTER: Agac A 

PROVIDER: S-EPMC12634557 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature