Identification of novel phenotypes in pediatric sepsis based on blood glucose trajectories.

ABSTRACT:

Objective

Metabolic heterogeneity in sepsis is a critical determinant of prognosis. This study applied group-based trajectory modeling (GBTM) to identify blood glucose trajectory phenotypes in pediatric sepsis and elucidate their associations with clinical outcomes.

Methods

A retrospective cohort study was conducted, enrolling 1,178 pediatric patients diagnosed with sepsis who were admitted to the pediatric intensive care unit of the Children's Hospital of Chongqing Medical University between 2014 and 2022. Dynamic blood glucose data were collected within 72 h of ICU admission, and GBTM was employed to classify trajectory phenotypes. Multivariate logistic regression was used to identify independent predictors of in-hospital mortality. A subgroup analysis focused specifically

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12634563 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature