A fingerprint approach to pioneer structure-based T cell receptor repertoire analysis and specificity prediction.

ABSTRACT:

Introduction

The development of cancer immunotherapy has accelerated in recent years. Understanding the specificity of T cell receptors (TCR) for peptides presented by the major histocompatibility complex (pMHC) is a critical step towards improving immunotherapy approaches, such as adoptive cell transfer and peptide vaccination. Despite notable computational advances, the unambiguous pairing of TCR with pMHC, from pools of thousands of candidates and unseen pMHC, remains elusive.

Methods

To meet this challenge and showcase the potential of using physics-based structure-based methods without being hindered by their computational cost, we developed a novel approach, TCRfp. This method transforms the 3D structure of TCRs into one-dimensional structural fingerprints (FPs) using

SUBMITTER: Mayol-Rullan F 

PROVIDER: S-EPMC12634567 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature