Neuro-functional correlates of personality dimensions in Parkinson's disease.

ABSTRACT:

Introduction

According to the original model of the Temperament and Character Inventory (TCI), personality dimensions would be related to different neurotransmitters' systems such as the dopaminergic and the serotoninergic ones.

Methods

Our objective was to study associations between functional connectivity and personality in Parkinson's disease (PD). The data of 29 PD patients were collected (NCT04705207). It included personality evaluation using the TCI, functional connectivity from resting-state functional MRI, and anxio-depressive state from the Hospital Anxiety and Depression scale (HAD). Seed-to-voxels and ROI-to-ROI analyses were done in the CONN toolbox.

Results

Significant association was found between Novelty Seeking scores and functional connectivity within

SUBMITTER: Boussac M 

PROVIDER: S-EPMC12634589 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature