The effect of esketamine on postoperative delirium in patients undergoing general anesthesia: a systematic review and meta-analysis.

ABSTRACT:

Background

Postoperative delirium (POD), a prevalent neurological complication, is strongly associated with adverse clinical outcomes. This meta-analysis aimed to evaluate the efficacy of esketamine in preventing POD among patients receiving general anesthesia.

Methods

We systematically searched PubMed, Embase, Cochrane Library, Web of Science, clinical trial registries and major conference proceedings for randomized controlled trials (RCTs) examining esketamine's impact on POD in general anesthesia patients, from inception through 30 June 2025. Statistical analyses were performed using RevMan 5.4 and Stata 12.0. Dichotomous outcomes were expressed as risk ratios (RR) with 95% confidence intervals (CI), while continuous variables were analyzed via mean differences (MD). Stud

SUBMITTER: Chao-Xu 

PROVIDER: S-EPMC12634593 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature