Investigating the role of <i>Akkermansia muciniphila</i> Akk11 in modulating obesity and intestinal dysbiosis: a comparative study of live and pasteurized treatments.

ABSTRACT:

Introduction

Obesity has become a major global health concern and is closely associated with imbalances in gut microbiota and chronic low-grade inflammation. Probiotics have been explored for their potential to prevent or alleviate obesity, especially in the case of Akkermansia muciniphila. While the standard strain A. muciniphila ATCC BAA-835 has been shown to help reduce obesity, significant functional variations among different strains remain a concern. To address this issue, our research investigated the impact of A. muciniphila Akk11 (Akk11), a strain sourced from the feces of healthy infants, in both its live and pasteurized forms on obesity.

Methods

Male C57BL/6J mice were fed a high-fat diet to induce obesity and then treated with either live or

SUBMITTER: Feng S 

PROVIDER: S-EPMC12634622 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature