Attenuation of sepsis-induced myocardial injury by Xiangdan injection via mitochondrial protection and inflammation suppression in mice.

ABSTRACT:

Background

Sepsis-induced myocardial injury (SIMI) is a leading cause of organ dysfunction and mortality in septic patients. Effective myocardial-protective therapies remain limited.

Objective

This study evaluated the cardioprotective effects of Xiangdan injection in murine SIMI models caused by both Gram-positive and Gram-negative bacteria.

Methods

Male C57BL/6 mice were assigned to sham, sepsis, and three Xiangdan dose groups for each bacterial model using a randomization schedule. Xiangdan injection was administered by oral gavage 12 h before and immediately after bacterial challenge (prophylaxis/early intervention). Outcomes included survival, serum inflammatory cytokines, cardiac biomarkers, histopathology, and ultrastructural mitochondrial integrity.

Results<

SUBMITTER: Chang Y 

PROVIDER: S-EPMC12634624 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature