The cumulative social adversity hypothesis of psychosis: Intolerance of uncertainty and aberrant salience mediate the association between humiliation and psychotic-like experiences.

ABSTRACT:

Background

The social defeat hypothesis, here framed as cumulative social adversity (CSA) to avoid disempowering terminology, posits that individuals with long-term experience of an unwanted, subordinate position present an elevated risk of psychosis. It has been observed that humiliation might be the most central component of the CSA hypothesis that increases the risk of psychosis through specific information processing patterns. The present study aimed to further investigate as to whether two cognitive processing patterns, i.e., aberrant salience (AS) and intolerance of uncertainty (IU), play a mediating role in the association between CSA and psychotic-like experiences (PLEs).

Methods

A total of 1308 non-clinical young adults (aged 31.1 ± 5.9 years, 47.9% men) were assess

SUBMITTER: Bielawski T 

PROVIDER: S-EPMC12634645 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature