Detecting early kidney allograft fibrosis with multi-b-value spectral diffusion MRI.

ABSTRACT: Kidney allograft fibrosis is a manifestation of chronic kidney disease (CKD) and predicts functional decline, and eventual allograft failure. This study evaluates whether spectral diffusion magnetic resonance imaging (MRI) detects early development and mild/moderate fibrosis in kidney allografts. In a prospective two-center study of kidney allografts, pathologic interstitial fibrosis and tubular atrophy (IFTA) was scored and eGFR was calculated from serum creatinine. Multi-b-value diffusion-weighted imaging (DWI) ([Formula: see text]]) was post-processed with spectral diffusion, intravoxel incoherent motion (IVIM), and apparent diffusion coefficient (ADC). Relationships between imaging parameters and biological processes were measured by Mann-Whitney U-test and Spearman's rank; diagnostic

SUBMITTER: Liu MM 

PROVIDER: S-EPMC12634676 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature