CD200R1 modulates myelin phagocytosis and spleen response following spinal cord injury.

ABSTRACT: The interaction between CD200 and its receptor CD200R1 plays a key role in modulating immune responses in nervous system disorders. This study explored the function of CD200R1 in local and systemic inflammation following spinal cord injury (SCI) using CD200R1-knockout (CD200R1^-/-) mice. Following a low thoracic contusion injury, CD200R1^-/- mice exhibited increased macrophage infiltration at the injury site, with a greater proportion of pro-inflammatory Ly6C + macrophages. Myelin phagocytosis was impaired in CD200R1^-/- macrophages both ex vivo and in vitro, indicating a reduced capacity to clear myelin debris. Despite these immune alterations, CD200R1 deficiency did not affect spontaneous locomotor recovery post-SCI, as measured by the Basso Mouse Scale. How

SUBMITTER: Pannunzio B 

PROVIDER: S-EPMC12634686 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature