The LuxR family regulator SAV111 enhances avermectin production by binding to aveA1 gene promoter in Streptomyces avermitilis.

ABSTRACT: Avermectins, macrocyclic lactones produced by Streptomyces avermitilis, serve as essential therapeutic and agrochemical agents. LuxR-type transcriptional regulators are multifunctional proteins known to orchestrate antibiotic biosynthesis alongside virulence modulation, biofilm dynamics, and host immune interactions. However, no prior studies have characterized LuxR-family proteins as direct regulators of avermectin biosynthesis. This study delineates the mechanism through which SAV111, a LuxR-family transcriptional activator, enhances avermectin biosynthesis. Batch fermentation of the SAV111-overexpressing strain demonstrated dual functionality: (1) significant upregulation of avermectin titers and (2) accelerated hyphal growth kinetics. Developmental profiling revealed precocious morphol

SUBMITTER: Luo S 

PROVIDER: S-EPMC12634728 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature