A retrospective natural history study in adult and juvenile patients with incident dermatomyositis and polymyositis using real world data.

ABSTRACT:

Objective

This retrospective natural history study used real-world data to describe baseline demographics, comorbidities, clinical characteristics, and treatments, and assess incidence rates (IRs) of extra-muscular outcomes in patients with incident dermatomyositis (DM), polymyositis (PM), juvenile DM (JDM), and juvenile PM (JPM).

Methods

De-identified clinical data were collected from the US Optum® electronic health records with supplemental claims (01 January 2016 to 31 March 2021). Total 9,009 patients were included (DM: 4,275; PM: 4,559; JDM: 128; JPM: 47). IRs of 13 outcomes were estimated in patients and an equal number of sex- and age-matched controls (MCs) without DM/PM.

Results

Mean age at index was 54.5 (DM), 57.3 (PM), 14.3 (JDM), and 15.1 years (JPM). Most

SUBMITTER: Barnes DM 

PROVIDER: S-EPMC12634748 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature