SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mice.

ABSTRACT: NUT carcinoma (NC) is an aggressive malignancy driven by BRD4::NUTM1 and other NUTM1 fusion oncogenes. BRD4::NUTM1 aberrantly activates transcription factors (TFs) associated with basal progenitor cells of stratified epithelium, resulting in a poorly differentiated squamous cell carcinoma (SCC) phenotypes. Among these TFs, SOX2 has been proposed as a critical driver. However, its role in NC initiation and progression has not been investigated in vivo. Using a genetically engineered mouse model that faithfully recapitulates human NC, we performed lineage-specific conditional deletion of Sox2 in both squamous and non-squamous tissues during NC oncogenesis. We found that SOX2 is dispensable for NC initiation and progression, and that tumors lacking SOX2 retain characteris

SUBMITTER: Luo C 

PROVIDER: S-EPMC12634820 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature