Evaluation and optimization of mumps-containing vaccination strategies: a study based on an individual-based stochastic model.

ABSTRACT:

Background

The measles-mumps-rubella (MMR) trivalent vaccine constitutes a cornerstone in controlling mumps incidence. However, variations in vaccination timing coupled with the gradual waning of vaccine-induced immunity have contributed to an increase in mumps cases among adolescents, alongside dynamic shifts in age distribution. This study aims to elucidate the optimal vaccination strategies for both the general population and age-specific cohorts through a comprehensive, multidimensional evaluation.

Methods

We systematically collected and integrated global annual average mumps incidence data (2000-2023) from 23 countries and immunization schedule databases to construct 16 hypothetical vaccination strategies, including the baseline regimen (a single dose administered at 18

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12634841 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature