Nitrate maintains mitochondrial membrane integrity by increasing Sialin-FKBP8 granules via liquid-liquid-phase separation.

ABSTRACT: Mitochondria, the metabolic centers of cells, play a pivotal role in maintaining cellular homeostasis and regulating physiological processes. Mitochondrial membrane disruption and consequent dysfunction are key pathogenic mechanisms underlying various diseases, including irradiation (IR)-induced salivary gland damage. Our previous studies have demonstrated that nitrate exerts preventive effects against mitochondrial dysfunction and IR-induced salivary gland injury. However, the mechanism remains unclear. In the present study, supplementation with nitrate significantly reduced mitochondrial damage to salivary epithelial cells in the context of IR-induced salivary gland damage in vivo and cellular injury to human salivary gland cells (HSGs) in vitro. Nitrate alleviated mitochondrial membrane

SUBMITTER: Wang X 

PROVIDER: S-EPMC12634865 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature