Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function.

ABSTRACT: Cardiac aging is an intrinsic process that leads to impaired heart function, along with cellular and molecular changes. Recent research highlights the important role of mitochondria in cardiac function, due to the heart's high energy demands. Serum response factor (SRF), a transcription factor involved in regulating actin and smooth muscle gene expression, is well known as a regulator of various aspects of cardiac function. However, its role in mitochondrial regulation and cardiac aging is poorly understood. Our laboratory generated a transgenic mouse model with cardiac-specific overexpression of SRF, which exhibits characteristics of diastolic dysfunction and accelerated cardiac aging in young adult transgenic mice. In this study, we tested how cardiac-specific overexpression of SRF affec

SUBMITTER: Patyal P 

PROVIDER: S-EPMC12634980 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature