Dual chitosan hydrogel and polylactic acid microparticle delivery system reduces Staphylococcal osteomyelitis and soft tissue infection.

ABSTRACT: Osteomyelitis, an infection of bone, is traditionally treated with long-term, systemic, high-dose antibiotics, which can lead to kidney and liver damage and accelerate the development of antibiotic resistance. Localized delivery may mitigate these risks by delivering antimicrobial(s) directly to the site of infection. Herein, innately antimicrobial chitosan hydrogel (CH) containing polylactic acid (PLA) microparticles, each loaded with fosfomycin antibiotic, was used to combat a biofilm-forming strain of Staphylococcus aureus. This dual CH + PLA biomaterial treatment mitigated S. aureus in planktonic and biofilm form in vitro, and in a clinically relevant, implant-associated rat model of chronic osteomyelitis. Notably, only the CH + PLA biomaterial treatment led to a reduction in bone defe

SUBMITTER: Tucker LJ 

PROVIDER: S-EPMC12635059 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature