Placenta-derived extracellular vesicles in maternal plasma of Hb Bart's fetuses.

ABSTRACT: Hemoglobin (Hb) Bart's disease is the most common cause of hydrops fetalis among Southeast Asians. Given its high fatality rate, prenatal diagnosis and treatment are the key. This condition is associated with placental hypoxia, which can trigger the release of placenta-derived extracellular vesicles (EVs) into the maternal circulation. We aimed to determine the levels of placenta-derived EVs and the proteomic profiles of plasma EVs in women with fetuses with Hb Bart. This prospective cohort study included women with: (1) normal term pregnancies (Group 1; n = 19); (2) Hb Bart's fetuses with hydropic features (Group 2; n = 4); (3) Hb Bart's fetuses without hydrops (Group 3; n = 7); (4) placental associated complications (a disease control group or Group 4; n = 4); and (5) hydrops fetalis fro

SUBMITTER: Chaemsaithong P 

PROVIDER: S-EPMC12635114 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature