Combined protection against UVB-induced photoaging by oleuropein, hydroxytyrosol, and verbascoside through modulation of inflammation, oxidative stress, and collagen homeostasis.

ABSTRACT: Ultraviolet B (UVB) exposure induces skin photoaging through triggering oxidative stress, inflammation, apoptosis, and collagen degradation. Oleuropein (OLE), Hydroxytyrosol (HT), and Verbascoside (Verb) are polyphenols derived from olive leaves, exhibiting potent antioxidant and anti-inflammatory properties. In the present study, we investigated the protective effects of OLE, HT, and Verb combination (O/H/V) against UVB-induced photoaging using in vitro models. The results showed that O/H/V treatment reduced the expression of senescence and apoptosis-related markers, while concurrently downregulated inflammatory factors and matrix metalloproteinases via suppression of MAPK and NF-κB pathways in UVB-irradiated HDF cells. In UVB-irradiated HaCaT cells, O/H/V treatment attenuated collagen de

SUBMITTER: Wang J 

PROVIDER: S-EPMC12635131 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature