Attenuated cognitive control network connectivity as a mechanism in mother-daughter intergenerational transmission of depression: a preliminary study.

ABSTRACT: Identifying brain mechanisms implicated in the intergenerational transmission of major depressive disorder (MDD) is crucial for early detection and developing novel interventions. One promising mechanism involves altered intrinsic connectivity patterns in brain networks supporting emotion processing, including within the cognitive control network (CCN). The current preliminary study used resting state functional magnetic resonance imaging (fMRI) to examine whether altered CCN connectivity patterns are a brain-based mechanism of intergenerational risk for depression. We tested whether CCN connectivity patterns (1) differentiated mothers with and without recurrent MDD, (2) differentiated their high-risk (HR) and low-risk (LR) daughters, and (3) served as prospective predictors of daughters'

SUBMITTER: Burkhouse KL 

PROVIDER: S-EPMC12635134 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature