Fetal malformations in women with pregestational diabetes mellitus based on pre-pregnancy fasting plasma glucose levels.

ABSTRACT: To evaluate the risk of fetal malformation in pregnant women with pregestational diabetes mellitus based on pre-pregnancy fasting plasma glucose (FPG) levels. This cohort study used the Korean Health Insurance Review and Assessment (HIRA) database, including 5,687 women with pre-pregnancy diabetes and FPG measurements within one year before conception. Subjects were grouped into three glycemic level categories: low (FPG < 100 mg/dL [< 5.5 mmol/L]), moderate (FPG: 100-125 mg/dL [5.6-6.9 mmol/L]), and high (FPG ≥ 126 mg/dL [≥ 7.0 mmol/L]). The low glycemic group was divided into four subgroups based on FPG levels. The relative risks of fetal malformations were calculated using multivariable analysis compared to a reference group (FPG < 84 mg/dL [< 4.7 mmol/L]). Fetal malformation rates were

SUBMITTER: Hong S 

PROVIDER: S-EPMC12635161 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature