Personalized neurometabolic signature predicts seizure outcomes of laser ablation in mesial temporal lobe epilepsy.

ABSTRACT:

Background

Mesial temporal lobe epilepsy (mTLE) is a common form of drug-resistant epilepsy and seizure outcomes after minimally invasive laser ablation remain suboptimal. Current imaging-guided strategies often fail to capture individual variability in seizure foci. This study aimed to develop a personalized neuroimaging biomarker to improve surgical planning and predict outcomes.

Methods

Thirty patients with mTLE (16 women, 53.3%; age range 17-59 years) who underwent magnetic resonance-guided laser interstitial thermal therapy were retrospectively analyzed. The asymmetry index (AI) from [¹⁸F]fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG PET) defined the personalized NeuroMetabolic Signature (pNMS). Prognostic thresholds and optimal pNMS ab

SUBMITTER: Mo J 

PROVIDER: S-EPMC12635162 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature