Early CMV DNAemia during letermovir prophylaxis predicts lower risk of late CMV infection and is associated with enhanced T-cell immunity after alloHSCT.

ABSTRACT: CMV-specific immune monitoring may support individualized risk stratification after allogeneic hematopoietic stem cell transplantation (alloHSCT), but its role in the era of letermovir prophylaxis remains unclear. In this prospective single-center study, 45 CMV-seropositive alloHSCT recipients receiving letermovir prophylaxis for 100 days post-transplant were followed for 12 months. CMV-specific T-cell responses to IE-1 and pp65 were assessed by IFN-γ ELISpot on days 100 and 200, and at the time of CMV infection and follow-up. Early CMV infection occurred in 18/45 patients (40%) during prophylaxis, of which 16 (88.9%) were transient "blips" and required no pre-emptive therapy. In univariate logistic regression, early CMV infection was associated a significantly lower risk of late CMV infec

SUBMITTER: Duplessix T 

PROVIDER: S-EPMC12635171 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature