Post-attachment neutralization of HPV16 by antibodies derived from Gardasil-vaccinated women.

ABSTRACT: HPV vaccines exhibit high type-specific and antibody-mediated protection against anogenital infection, even after a single dose. Complete and long-term "sterilizing" immunity against incident infection appears to be established in most HPV vaccinees, suggesting that not only are persistent levels of virus-inhibiting antibodies routinely generated but that they are also exceptionally potent at preventing infection. The process of HPV infection is unusually protracted at several steps, including slow internalization after the virions bind to the cell surface. This observation prompted us to comprehensively evaluate the ability of neutralizing antibodies to prevent infection subsequent to HPV pseudovirion attachment to cells. Using sera and memory B cell-derived monoclonal antibodies from Gar

SUBMITTER: Day PM 

PROVIDER: S-EPMC12635185 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature