BICD2 promotes ciliogenesis by facilitating CP110 removal from the mother centriole.

ABSTRACT: Cilia are hair-like organelles that protrude from the cell surface and play vital roles in embryonic development and tissue homeostasis. Removal of centriolar coiled-coil protein 110 (CP110) from the mother centriole is a critical step in ciliogenesis, yet the underlying mechanism remains largely unknown. In this study, we identify bicaudal D cargo adaptor 2 (BICD2) as a mother centriole protein that directly binds CP110 and facilitates its removal to promote ciliogenesis. Depletion of BICD2 significantly inhibits ciliogenesis and the removal of CP110, whereas knockdown of CP110 rescues ciliogenesis defects in BICD2-deficient cells. Additionally, we show that BICD2 is recruited to the mother centriole during ciliogenesis, where it directly binds and removes CP110. Moreover, zebrafish bicd2

SUBMITTER: Kuang W 

PROVIDER: S-EPMC12635215 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature