Macrophage mitophagy-related genes predict prognosis and therapeutic response in lung adenocarcinoma.

ABSTRACT: Mitochondrial autophagy (mitophagy) in macrophages is crucial yet poorly understood within the lung adenocarcinoma (LUAD) tumor microenvironment. This study aimed to identify key macrophage mitophagy-related genes and develop a robust prognostic model for LUAD patients. By integrating single-cell transcriptomics with machine learning algorithms, including LASSO, SVM, and random forest, we identified TUBB6 and CAT as core prognostic genes. A novel risk model based on these genes (RiskScore = 0.225 × TUBB6 - 0.19 × CAT) was constructed and validated, demonstrating that patients in the high-risk group had significantly shorter overall survival (P < 0.001). The high-risk score also correlated with an altered immune microenvironment and increased sensitivity to chemotherapies like cisplatin and

SUBMITTER: Yang T 

PROVIDER: S-EPMC12635252 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature