Afferent input differentially regulates establishment and maintenance of synapses in the mammalian retina.

ABSTRACT: How afferent input shapes synaptic connections is fundamental to our understanding of cues that govern assembly of sensory circuits. In the retina, photoreceptors provide afferent visual information to second-order bipolar cells (BCs) that in turn transfer signals to output neurons. BCs have distinct inhibitory synapses at dendrites and axons but the role of afferent input for regulating the composition and function of these synapses remains unknown. We used a photoreceptor degeneration murine transgenic with labeled BCs and combined immunohistochemical assessment of synaptic proteins across timepoints with single-cell electrophysiology and transcriptomics to address how photoreceptor input regulates BC synapses. We find that inhibitory synapses across BCs have distinct dependencies on aff

SUBMITTER: Wallin J 

PROVIDER: S-EPMC12635312 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature